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Insulin resistance

14/10/2026 | News

New publication: Hepatic Overexpression of a Novel Soluble Endogenous Transforming Growth Factor β Type II Receptor−Immunoglobulin G1 Fc Fusion Protein (TβRII-SE/Fc) Attenuates Early Stage Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats
Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in the regulation of liver fibrosis and metabolism. Previously, we have demonstrated the antifibrotic effect of TβRII-SE/Fc delivered by a lentiviral vector (Lv) in a liver fibrosis model. TβRII-SE/Fc is a fusion protein composed of the soluble isoform of the TGF-β type...

14/10/2026 | Noticias

Nueva publicación: "Lentiviral-Mediated expression of a novel transforming growth factor-β (TGF-β) inhibitor peptibody therapeutically mitigates established liver fibrosis by modulating inflammation and inducing metabolic reprogramming"
El factor de crecimiento transformante β (TGF-β) es una citoquina pleiotrópica involucrada en la regulación de la fibrosis hepática, el metabolismo y la resistencia a la insulina (IR), lo que lo posiciona como un blanco terapéutico relevante en la progresión de MASLD. Recientemente se identificó una nueva variante de splicing del...