Stem Cells and Gene Therapy Laboratory

La Colla A, Cámara CA, Rodríguez TM, Echarte SM, Alomar ML, Chisari AN, Dewey RA. Lentiviral-Mediated Expression of a Novel Transforming Growth Factor-β (TGF-β) Inhibitor Peptibody Therapeutically Mitigates Established Liver Fibrosis by Modulating Inflammation and Inducing Metabolic Reprogramming. ACS Pharmacology & Translational Science . En prensa. https://doi.org/10.1021/acsptsci.5c00817

Romo A, Rodriguez TM, Yu G, Dewey RA. Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts. Cancer Gene Therapy 31, 174-185. 2024.  https://doi.org/10.1038/s41417-023-00694-z

Andreone L, Fuertes F, Sétula C, Barcala Tabarrozzi AE, Orellano MS, Dewey RA, Bottino R, De Bosscher K, Perone MJ. Compoun A attenuates proinflammatory cytokine-induced endoplasmic reticulum stress in beta cells and displays beneficial therapeutic effects in a mouse model of autoimmune diabetes. Cellular and Molecular Life Sciences 79, 587. 2022. https://doi.org/10.1007/s00018-022-04615-5

Bertolio MS, La Colla A, Carrea A, Romo A, Canziani G, Echarte SM, Campisano S, Barletta GP, Monzon AM, Rodríguez TM, Chisari AN, Dewey RA. A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo. Frontiers in Cell and Developmental Biology 9, 630397. 2021. https://doi.org/10.3389/fcell.2021.690397

Carrea A, Preisegger MA, Zamora JV, Dewey RA. The mRNA levels of TGF-β Type II receptor splice variants in monocytes are associated with disease activity in patients with rheumatoid arthritis. Clinical and Experimental Rheumatology 39, 310-318. 2021. PMID: 32452354

Yu G, Fu J, Romo A, Li B, Liu H. Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation. Journal of Molecular Cell Biology 12, 738-740. 2020. https://doi.org/10.1093/jmcb/mjaa022